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Monday, March 7, 2011

US farmers fear the return of the Dust Bowl - Nông dân Mỹ lo sợ Chảo Bụi quay lại

US farmers fear the return of the Dust Bowl - Nông dân Mỹ lo sợ Chảo Bụi quay lại

For years the Ogallala Aquifer, the world’s largest underground body of fresh water, has irrigated thousands of square miles of American farmland. Now it is running dry

The town of Happy, Texas

The town of Happy, Texas, sits on top of the rapidly depleting Ogallala Aquifer. Its population is dwindling by 10 per cent a year. Photo: Misty Keasler

There is not much to be happy about these days in Happy, Texas. Main Street is shuttered but for the Happy National Bank, slowly but inexorably disappearing into a High Plains wind that turns all to dust. The old Picture House, the cinema, has closed. Tumbleweed rolls into the still corners behind the grain elevators, soaring prairie cathedrals that spoke of prosperity before they were abandoned for lack of business.

Happy's problem is that it has run out of water for its farms. Its population, dropping 10 per cent a year, is down to 595. The name, which brings a smile for miles around and plays in faded paint on the fronts of every shuttered business – Happy Grain Inc, Happy Game Room – has become irony tinged with bitterness. It goes back to the cowboy days of the 19th century. A cattle drive north through the Texas Panhandle to the rail heads beyond had been running out of water, steers dying on the hoof, when its cowboys stumbled on a watering hole. They named the spot Happy Draw, for the water. Now Happy is the harbinger of a potential Dust Bowl unseen in America since the Great Depression.

'It was a booming town when I grew up,' Judy Shipman, who manages the bank, says. 'We had three restaurants, a grocery, a plumber, an electrician, a building contractor, a doctor. We had so much fun, growing up.' Like all the townsfolk, she knows why the fun has gone. 'It's the decline in the water level,' she says. 'In the 1950s a lot of wells were drilled, and the water went down. Now you can't farm the land.'

Those wells were drilled into a geological phenomenon called the Ogallala Aquifer. It is an underground lake of pristine water formed between two and six million years ago, in the Pliocene age, when the tectonic shifts that pushed the Rocky Mountains skywards were still active. The water was trapped below the new surface crust that would become the semi-arid soil of the Plains, dry and dusty. It stretches all the way down the eastern slope of the Rockies from the badlands of South Dakota to the Texas Panhandle. It does not replenish.

Happy is the canary in the coalmine because the Ogallala is deepest in the north, as much as 300ft in the more fertile country of Nebraska and Kansas. In the south, through the panhandle and over the border to New Mexico, it is 50-100ft. And around Happy, 75 miles south of Amarillo, it is now 0-50ft. The farms have been handed over to the government's Conservation Reserve Programme (CRP) to lie fallow in exchange for grants: farmers' welfare, although they hate to think of it like that.

The first ranchers, and the Plains Indians before them, knew of water below the ground from the watering holes that sustained buffalo and then cattle far from any river. The white man learnt to drill, leaving primitive windmills on top of wooden derricks silhouetted against Wild West horizons.

But it was only in the 1940s, after the Dust Bowl (the result of a severe drought and excessive farming in the early 1930s), that the US Geological Survey worked out that the watering holes were clues to the Ogallala, now believed to be the world's largest body of fresh water. They were about to repeat the dreams of man from the days of Ancient Egypt and Judea to turn the desert green, only without the Nile or Jordan. With new technology the wells could reach the deepest water, and from the early 1950s the boom was on. Some of the descendants of Dust Bowl survivors became millionaire landowners.

'Since then,' says David Brauer of the US Agriculture Department agency, the Ogallala Research Service, 'we have drained enough water to half-fill Lake Erie of the Great Lakes.' Billions upon billions of gallons – or, as they prefer to measure it, acre-feet of water, each one equivalent to a football field flooded a foot deep – have been pumped. 'The problem,' he goes on, 'is that in a brief half-century we have drawn the Ogallala level down from an average of 240ft to about 80.'

Brauer's agency was set up in direct response to the Dust Bowl, with the brief of finding ways to make sure that the devastation never happens again. If it does, the impact on the world's food supply will be far greater. The irrigated Plains grow 20 per cent of American grain and corn (maize), and America's 'industrial' agriculture dominates international markets. A collapse of those markets would lead to starvation in Africa and anywhere else where a meal depends on cheap American exports. 'The Ogallala supply is going to run out and the Plains will become uneconomical to farm,' Brauer says. 'That is beyond reasonable argument. Our goal now is to engineer a soft landing. That's all we can do.'

Estimates vary, but with careful conservation, less wasteful irrigation and seeds for corn, cotton, wheat and sorghum genetically engineered for drought conditions, farming may yet go on for 60 years. That would be over the deepest stratum of the Ogallala. But the husbanding of water, soil, minerals or anything else has never been the Texan way, and without it the dust will start blowing in as few as 10 years.

Water – not oil – has always been the most valuable resource in the West. Wars have been fought over it, feuds maintained, and fortunes won or lost. Apart from the Ogallala, the main source remains the Colorado River, flowing west from the Rockies, its annual bounty of snow melt providing the drinking water for Las Vegas, irrigation for California's Central Valley, and the swimming-pools of Los Angeles. No one is surprised that the mighty Colorado now runs dry before it reaches the Pacific, nor that climate change, with falling rain and snow levels, spells potential disaster for the Sunshine States. There are at least public controls over most of this water, even if it is actually owned by corporations and very rich people with 'water rights'.

But Texas, true to its self-conscious style of 'rugged individualism', has no such legal controls. It maintains its Wild West-era laws of 'right to capture'. This means that if you have water under your land, or in a river running through it, you can take and use as much of it as you like. You can water the corn or the cows, or you can make a buck by selling it to the nearest thirsty suburb. If you want to drain your land into desert, you may.

With the American 'can-do' faith in technology, Brauer's own hopes are for the 60-odd years of reduced but viable farming. 'We don't want it to be a bust,' he says. 'We have to be optimistic.'

In Happy, that sounds more like wishful thinking. The early December sun sinks towards the winter solstice at a few minutes after six, leaving Main and its crossroads with the railway tracks in darkness but for a few street lights. A miniature suburban-style housing grid stretches between Main and the high school on the eastern edge of town. The football team is the Happy Cowboys, their cheerleaders the Happy Cowgirls. Old pick-up trucks in the car-park denote an away match, their drivers piled into yellow school buses for the trip. Most of the houses are still lived in, valued at about half the Texas average. Some are dilapidated, their gardens planted with rusting detritus, others spruce with the Stars and Stripes flapping in the breeze. Nowadays, the working population drives an hour or so north or south to small cities where they find employment.

The temperature drops below freezing. Kay Horner sits in My Happy Place, her diner on Highway 87, hoping for traffic and customers. She has moved back from Arkansas, snapping-up a Main Street store for only $10,000 to turn into her home. 'There used to be 50,000 head of cattle, now there's 1,000,' she says. 'Grazed them on wheat, but the feed lots took all the water so we can't grow wheat. Now the feed lots can't get local steers so they bring in cheap unwanted milking calves from California and turn them into burger if they can't make them veal. It doesn't make much sense. We're heading back to the Dust Bowl.'

Less than 20 miles south, towards Lubbock, the next town down Interstate 27, Barry Evans is still farming. His 2,200 acres came from his great-uncle Freeman, who watched it turn to dust in the 1930s. Evans's father, in his eighties, still works the farm next door. Evans has sunk new wells to make up supply as old ones dry from producing 1,000 gallons a minute to 100, but the aquifer is deeper here and they have enough Ogallala water left to pump and make a profit. They want to make it last, their eyes fixed on the future so that Barry's son, Eric, can take over for a fourth generation. He is in his last year at high school and is raising four pigs of his own for the 4H (young farmers) competition at the County Fair. It will not be easy, but at 48 Evans has taken himself to the cutting edge of farm technique and technology. If there is a future for Ogallala farming, it depends on men such as Evans.

'You have to see this as a business like any other,' he says. 'To earn a living, to stay on the land, you have to maintain the margin between cost and product value. Our water level is 10 per cent of what it was 30 years ago, and we have to make up for that by technique. That means looking for more yield from less water.'

Evans went to the local university for an agriculture degree, and stayed on to complete half a master's in business. He does not own a cowboy hat, and pulls on a winter coat bearing the logo of a seed company, a salesman's gift, as he sets out to tour his 'sections', fields of a square mile each. At ground level the rows look faintly curved, but from the air you can see that the fields are circles, and from passenger jets at 30,000ft they look like the crop circles of Salisbury Plain. They are ugly and alien on the wide-open land, but they have become the landscape of Ogallala agriculture because they are cut to fit the sweep of the enormous arm of a pivot irrigator, turning like the hand of a clock, a hand a half a mile long. They cost $180,000 each.

Evans stops by a well. There is no derrick, only a concrete block sprouting heavy pipes, because nowadays the pump is at the bottom of the well. Inside a steel box is a computer: it controls the pivoting arm to lay down an average of an inch in eight days. Every drop counts. On many farms you can see the effects of drought from the air as a quarter or a third of the land is left dry to burn brown in the sun. 'During the 90s, I really thought it would never rain again,' Evans says. 'But with a bit of luck, we get eight to 10 inches a year, and we have learnt to capture it. I aim for half-and-half, half rainfall and half aquifer.' He can now grow crops using five acre-inches a year, rather than acre-feet. 'That's a big difference,' he says.

He strides into the field along the line of the pivot arm, 12ft over his head. Every few yards a spray nozzle dangles on a hose, low enough to spray below the canopy of the crops. That is one way to minimize waste through evaporation. Next, he stoops to the soil to show the flattened stubble of last year's crop, and of the year's before that. He no longer ploughs – nothing dries the surface to turn the soil to dust like ploughing. Instead, the old stalks hold down the soil, keep the moisture in, and rot down to nutrients. The seeds, themselves 'engineered', are dropped below the surface by a machine that opens a narrow channel in front of the dispenser, and closes it behind them.

Then there is the choice of crops. Evans has switched from corn, wheat and cattle to cotton and sorghum, which makes oil and ethanol for fuel, alternating them around his circular fields. They use less water, and he has got rid of the cattle altogether. 'I don't want to drill more wells,' he says. 'Why would I want to own a desert?'

At the Ogallala Research Service's experimental farm just west of Amarillo, soil scientist Steve Evett nods his approval and says, 'The smart, educated farmer survives: the ones that fall behind do not.' He is out in his half-sized 'pivot' field, showing off the next generation of irrigation systems. This one is fully automated and, with a bit of luck, may save another drop or two. It starts with a new nozzle, a 'sock', which drips the water right on to the ground by each root. Between each dangling pipe is a cable with a sensor at one end, and a computer relay at the other. It measures the amount of moisture in the canopy, and takes a light-spectrum scan of each plant to determine its health, just as the gardener judges the colour of his leaves. This information goes back to the computer mounted at the well-head for even finer metering.

In another field, there is what might become the last resort: a system buried underground, watering only individual roots, with evaporation limited to any that might reach the surface. 'We are already seeing much less water used,' Evett says, 'and there is going to be less and less to use. Things will get harder and harder, but we can use technology to offset the drying for as long as we can.'

All may come to nought in the face of a threat that has nothing to do with corn or beef, but everything to do with the American devotion to making money at any cost. The Texas oil billionaire and corporate raider T Boone Pickens is after their water. He is proving to be the ultimate test of their free market gospel of the 'right to capture'.

Ten years ago Pickens concluded that the prophets of climate-change may well be right, and if they were, that water would become more valuable than the oil that had made his fortune. He formed a company called Mesa Water, and began buying up Panhandle land with water rights over the Ogallala. He is now the largest individual water owner in America, with rights over enough of the aquifer to drain an estimated 200,000 acre-feet a year, at least until the land goes dry. That is 65 billion gallons a year, or, to put it another way, 124,000 gallons a minute. The plan? Ninety-five per cent of Ogallala water is now used for agriculture, but Pickens plans to pipe it 250 miles to Dallas, expected to triple in size in 30 years, with a demand for water far exceeding supply. Pickens is making the hottest of climate-change bets: that water's value will rocket as it runs dry. One man's thirst is another man's fortune. Irrigation farming would simply follow gold mining, open-range ranching and oil drilling in the traditional cycle of boom and bust. 'There are people who will buy the water when they need it. And the people who have the water want to sell it,' Pickens has said. 'That's the blood, guts, and feathers of the thing.'

'Obviously it would be a disaster for the Panhandle,' Steve Walthour, manager of the North Plains Groundwater Conservation District, says. 'But if there are no limits, he can take all he wants. That's the law of capture.'

Texas conservatives, at the core of America's faith-and-business culture, root for Pickens. Brent Connett, a policy analyst for the Texas Conservative Coalition Research Institute, pushes the view that trading farming for selling water is a 'right' upheld by 100 years of Texan law, and can only bring new prosperity. 'The water business, if allowed to bloom,' he believes, 'can be the advent of another multi-billion-dollar business that will tremendously benefit all Texans, especially those who hold the rights to the water in the Panhandle.'

Connett does not offer a count of winners versus losers. But a group of landowners in the far north of the Panhandle could certainly be winners. Taking advantage of another quirk of Texas law, they have voted against joining Walthour's Conservation District. That was their democratic right even as it defied the attempts of their fellow farmers to protect water supplies for the benefit of all. The other Ogallala states all have some form of government controls metering water use. Texas has the Conservation Districts instead, with the local farmers voting their own restrictions. The problem is that these are voluntary. 'The idea,' Walthour says, 'is to balance individual water rights with the common interest. It's the best thing to do. Otherwise the biggest pump wins – and everyone goes dry.'

Will Allen, among the 'opt-out' owners with a 'spread' close to the Oklahoma border, does not see it that way. 'In Kansas, the state owns the water – not so in Texas,' he says. 'We own it, and we don't see why we should give up our right to capture. We would be giving away property that belongs to us.' His family settled here in 1905 and he holds to their belief that the aquifer is less of a lake than a series of 'pockets', private to the land immediately above. Only the prospect of Pickens draining the water from underneath him seems to dent Allen's stand-alone verities. Would he chase him out of town? He chuckles, a little uncertainly. 'Well, I wouldn't want him as a neighbour,' he says. 'But if he takes out water he owns, that is his right.'

There is an air of fatality hanging over the farmers of the Panhandle. At the Elk Junction Restaurant in Stratford, a crossroads village 70 miles north of Happy at the heart of the 'opt-out' district, a group of half a dozen farmers has gathered to gossip over pies and coffee. Most are retired, or planning to quit, handing over to their sons if they want the land. Not all do. These men are mostly losing the struggle for water and the slender margins of profit that can keep them on the land. They have worked long and hard through often brutal weather, farming vast tracts with a couple of sons until they quit for college or city jobs. The land they have hung on to is worth a pension, as long as there is still some water for irrigation, but their real reward is their pride. To a man they loathe Pickens, while defending his 'right to capture'. This is Texas, and they are Texan.

The water boards would like to stop him but they know that state government would not dare challenge individual rights to ownership. Their only real chance is to persuade the county authorities to stall on 'zoning' permits when he starts to build his pipeline, and that is an outside chance.

'The heart of the Dust Bowl was here, you know,' says Wayne Plunk, whose great-great-grandfather came over from Germany. He is big and round, strong as an ox in his day, but now he looks a good 10 years older than his 69 years. 'When I was six I was asking my dad for a $1 umbrella against the sun for the tractor I drove all day. He said no, and bought me a 25-cent hat instead.' He has not stopped working since. He went to college to train as a teacher, and for 25 years taught at local schools while farming in the remaining hours. 'We are drying up. People don't learn from history, and if we keep breaking the ground and run out of water, it'll happen again.'

Plunk believes that one way or the other, farming the High Plains will have to end. Like the farmers of Happy, he has handed his land to the CRP to let it return to the Plains that nature intended. He misses the life. 'I used to go out on the land before dawn when I worked at school,' he says, 'and I would always plough to the east. I ploughed into the rising sun, and I knew there was a God.' He pushes back his cap, and stares into the distance.

The history of the NASA Space Shuttle in pictures

The history of the NASA Space Shuttle in pictures

Discovery lifts off from Kennedy Space Center

Discovery, NASA's oldest and most journeyed space shuttle, launches its final mission to the International Space Station, wrapping up a near three-decade legacy of orbital travel. Discovery has flown more missions than any other shuttle, circling the Earth more than 5,600 times and logging 142 million miles (230 million kilometres) over its 352 days in space. Final flights for the other two shuttles remaining in the US fleet, Atlantis and Endeavour, are scheduled for later this year. There were initially five space shuttles in the fleet - Challenger exploded shortly after liftoff in 1986 and Columbia disintegrated on its way back to Earth in 2003. The sixth shuttle, Enterprise, did test flights in the atmosphere but was never flown into space.

Alzheimer's drug may be tested on humans in 2 years

Alzheimer's drug may be tested on humans in 2 years

By Roger Highfield

Scientists have devised a new drug to fight the most common form of dementia that could be tested on patients within two years.

There are around three quarters of a million people in the UK with dementia and Alzheimer's is becoming increasingly common as the population ages. However, there are no effective treatments.

Now a new way to fight the devastating disorder has emerged from devising a novel way to prevent what some scientists believe is the underlying cause, the build up of protein deposits in the brain, and in precisely the place where this damage occurs.

The new drug was found to be effective when tested on fruit flies and mice that have been genetically engineered to develop the disease, showing that it could halve the harmful deposits in a few hours. Tests on humans are planned in around two years, after more testing on animals.

Today, in the journal Science, the team of academics at the Max Plank Institute, Dresden, led by the company Jado Technologies, describes how the new approach has emerged from the discovery of a way to target an enzyme that is central to the build up of deposits in the brain of a protein called beta amyloid.

The drug targets the membrane of brain cells, focusing on compartments in the membrane, called "rafts", that play a central role in many cellular processes.

Although this drug is not the first to target the enzyme, called beta secretase, it is the first to do so in the right place, in the "intracellular membrane compartment" where the enzyme triggers the protein deposit build-ups. The team has devised a way to anchor the drug to the membrane to stop the harmful deposits.

"Our data provide proof-of-principle of a new approach for directing small molecule inhibitors to disease causing raft targets in cellular membranes. In this instance, by directing inhibition to the sub-compartment where the enzyme is active, the approach has potential to be used in the design of more effective beta-secretase inhibitors for the treatment of Alzheimer's disease," noted Prof Kai Simons, Max-Planck Institute of Molecular Cell Biology and Genetics, Dresden, and co-founder of Jado.

In tests on animals, the drug reduced beta-amyloid formation in the brain by 50 per cent over four hours, when targeted this way. However, when not targetted at the membrane the drug was ineffective.

The key was using another molecule, called sterol, as the "anchor" for the enzyme inhibitor.

Dr Lawrence Rajendran, first author, believes that this way of anchoring drugs to the cell membrane is a "proof-of-principle" for an approach that could be crucial for treating many other diseases too, such as Ebola and Aids. "It is like hitchhiking into the cell: We use cellular strategies to deliver the inhibitors to the exact site where they are needed - and maybe, one day, to combat Alzheimer's disease."

"Routine animal studies have to be performed before we go to clinical trials," he says. "We expect that this might take about two years."

"This seminal paper is the culmination of many years pioneering research by this team in the emerging field of raft intervention therapeutics. At Jado we have taken this approach to the next level and are building a pipeline of compounds targeting rafts for the treatment of allergic disorders and infectious diseases," says Charl van Zyl, CEO.

Alzheimer's affects one in 20 of those over 65, causing loss of memory, personality changes and, eventually, death.

Researchers say they've found clue to Alzheimer's

WASHINGTON — Researchers have uncovered a new clue to the cause of Alzheimer's disease.

The brains of people with the memory-robbing form of dementia are cluttered with a plaque made up of beta-amyloid, a sticky protein. But there long has been a question whether this is a cause of the disease or a side effect. Also involved are tangles of a protein called tau; some scientists suspect this is the cause.

Now, researchers have caused Alzheimer's symptoms in rats by injecting them with one particular form of beta-amyloid. Injections with other forms of beta-amyloid did not cause illness, which may explain why some people have beta-amyloid plaque in their brains but do not show disease symptoms.

The findings by a team led by Dr. Ganesh Shankar and Dr. Dennis Selkoe of Harvard Medical School were reported in Sunday's online edition of the journal Nature Medicine.

The researchers used extracts from the brains of people who donated their bodies to medicine.

Forms of soluble beta-amyloid containing different numbers of molecules, as well as insoluble cores of the brain plaque, were injected into the brains of rats. There was no detectable effect from the insoluble plaque or the soluble one-molecule or three-molecule forms, the researchers found.

But the two-molecule form of soluble beta-amyloid produced characteristics of Alzheimer's in the rats, they reported.

Those rats had impaired memory function, especially for newly learned behaviours. Studies were also done on mice and when their brains were inspected, the density brain cells were reduced by 47 per cent. The beta-amyloid seemed to affect synapses, the connections between cells that are essential for communication between them.

The research, for the first time, showed the effect of a particular type of beta-amyloid in the brain, said Dr. Marcelle Morrison-Bogorad, director of the division of neuroscience at the National Institute on Aging, which helped fund the research.

It was surprising that only one of the three types had an effect, she said in a telephone interview.

Morrison-Bogorad said the findings may help explain the discovery of plaque in the brains of people who do not develop dementia. For some time, doctors have wondered why they find some brains in autopsy that are heavily coated with beta-amyloid, but the person did not have Alzheimer's.

The answer may lie in the two types of beta-amyloid that did not cause symptoms.

Now, the question is why one has the damaging effect and not others.

"A lot of work needs to be done," Morrison-Bogorad said. "Nature keeps sending us down paths that look straight at the beginning, but there are a lot of curves before we get to the end."

Dr. Richard Hodes, director of the National Institute on Aging, said that "while more research is needed to replicate and extend these findings, this study has put yet one more piece into place in the puzzle that is Alzheimer's."

In addition to the Institute on Aging, the research was funded by Science Foundation Ireland, Wellcome Trust, the McKnight and Ellison foundations and the Lefler Small Grant Fund.

Alzheimer's Disease Bệnh Alzheimer




Alzheimer's Disease

Bệnh Alzheimer

Dementia is a brain disorder that seriously affects a person's memory, thinking, and reasoning skills. People with dementia often have trouble thinking and speaking clearly, remembering recent events, and learning new things. Over time, it becomes hard for them to handle everyday activities and take care of themselves. There are many causes of dementia, but Alzheimer's disease is the most common cause of dementia in older persons.

Mất trí nhớ là một rối loạn não ảnh hưởng nghiêm trọng đến trí nhớ, tư duy và suy đoán của một người.Người bị chứng mất trí thường gặp khó khăn về tư duy và nói năng rành mạch, nhớ những sự kiện mới xảy ra, và học những điều mới. Theo thời gian, việc thực hiện các hoạt động hàng ngày và tự chăm sóc bản thân sẽ trở nên khó khăn đối với họ. Có những nhiều nguyên nhân của chứng mất trí nhớ, nhưng bệnh Alzheimer là nguyên nhân thông thường nhất của chứng mất trí nhớ ở người cao tuổi.

Scientists think that up to 4.5 million people in the United States suffer from Alzheimer's disease. The disease usually begins after age 65 and risk goes up with age. While younger people also may get Alzheimer's disease, it is much less common.

Các nhà khoa học nghĩ rằng có tới 4.5 triệu người ở Hoa Kỳ bị bệnh Alzheimer. Bệnh thường bắt đầu sau tuổi 65 và nguy cơ tăng dần lên theo tuổi tác. Những người trẻ hơn cũng có thể bị bệnh Alzheimer, nhưng ít phổ biến hơn nhiều.

About 5 percent of men and women ages 65 to 74 have Alzheimer's disease, and nearly half of those age 85 and older may have the disease. It is important to note, however, that Alzheimer's disease is not a normal part of aging.

Khoảng 5% nam giới và phụ nữ tuổi 65 đến 74 có bệnh Alzheimer, và gần một nửa số người 85 tuổi trở lên có thể mắc bệnh. Tuy nhiên, điều quan trọng cần lưu ý, là bệnh Alzheimer không phải là một phần bình thường của sự lão hóa.

Alzheimer's disease is named after Dr. Alois Alzheimer, a German doctor. In 1906, Dr. Alzheimer noticed changes in the brain tissue of a woman who had died of an unusual mental illness. He found abnormal clumps and tangled bundles of fibers. The clumps are now called amyloid plaques and the tangles are called neurofibrillary tangles. Today, these plaques and tangles in the brain are considered signs of Alzheimer's disease.

Bệnh Alzheimer được đặt tên theo Tiến sĩ Alois Alzheimer, một thầy thuốc người Đức. Năm 1906, Tiến Sĩ Alzheimer đã nhận thấy những thay đổi trong mô não của một người phụ nữ đã chết do một căn bệnh tâm thần bất thường. Ông đã tìm thấy các khối kết vi khuẩn bất thường và các bó sợi bị rối. Các khối kết vi khuẩn nay được gọi là các mảng bám amyl và các đám rối được gọi là các đám rối thần kinh. Ngày nay, các mảng kết bám và các đám rối trong não được coi là các dấu hiệu của bệnh Alzheimer.

Scientists also have found other brain changes in people with Alzheimer's disease. There is a loss of nerve cells and pathways in areas of the brain that are vital to memory and other mental abilities. There also are lower levels of some of the chemicals in the brain that carry complex messages back and forth between nerve cells. Alzheimer's disease may disrupt normal thinking and memory by blocking these messages between nerve cells.

Các nhà khoa học cũng đã tìm thấy các biến đổi khác ở não của bệnh nhân Alzheimer. Có sự tổn thương các tế bào thần kinh và đường dẫn truyền trong các vùng não quyết định ký ức và các năng lực tâm thần khác. Cũng có hàm lượng thấp trong não của một số hóa chất (làm công việc) chuyển các thông điệp phức tạp qua lại giữa các tế bào thần kinh. Bệnh Alzheimer có thể làm rối loạn tư duy và trí nhớ bình thường bằng cách ngăn chặn các thông điệp giữa các tế bào thần kinh.






It may have been ascribed a name more than a century ago, but Alzheimer’s disease — the most common form of dementia that makes people forget names, places and things and lose track of time and events irretrievably — still remains a mystery.

Science has so far failed to fully understand the exact cause of this brain disorder, let alone develop a cure. Alzheimer’s strikes at old age, occasional memory lapse being the first symptom. The condition deteriorates rapidly and those suffering from its severest forms may not be able to recognise even their closest family members. Moreover, the patients often experience delusions and hallucinations.

The name “Alzheimer’s disease” entered the medical lexicon in 1907 following a description of the condition by the German physician Dr Alois Alzheimer at a scientific meeting the year before. Dr Alzheimer happened to treat a female patient in 1901 who had some peculiar symptoms: problems with memory, unfounded suspicions about her husband’s fidelity and difficulty in speaking and understanding what was said to her. After her death — which was about five years later — he performed an autopsy on her, of course with her family’s permission. He found that her brain had shrunken dramatically, particularly in the cortex region, the outer layer involved in memory, thinking, judgement and speech.

Scientists may still not know the cause of the disease, but recent advances in neuro-imaging techniques have shown that those suffering from it have two abnormal structures in their brain: plaques formed of deposits of a sticky protein fragment called beta-amyloid, and tangled or twisted fibres of another protein called tau inside the dying nerve cells.

Actually, most people develop plaques and tangles as they age, but those with Alzheimer’s tend to form them on a much larger scale. Ever since the discovery of these unusual elements in the brain of Alzheimer’s patients, scientists have been trying to ascertain their role in triggering as well as in the progression of the disease.

There have been three independent studies recently — two of them involving Indian researchers — that have greatly enhanced scientists’ understanding of Alzheimer’s.

The first, by a team of researchers that included Ganesh Shankar and Tapan Mehta of Harvard Medical School, shows that all the beta-amyloid in an Alzheimer’s patient’s brain is not directly responsible for the disease. The work, led by Dennis Selkoe of the Centre for Neurologic Diseases at Harvard, is the first such study to unlock the cascade of molecular events that lead to this debilitating condition. The team also has researchers from University College, Dublin, and the Royal College of Surgeons in Ireland.

Selkoe and his team observed for the first time that beta-amyloid exists in various forms. While some of these survive as single molecules called monomers, there are others which are formed by two or more molecules of beta-amyloid that stick together and which are soluble. Then there are clumps which are not soluble at all.

The study, recently published in Nature Medicine, came up with an interesting finding. The scientists first isolated beta-amyloid from the brains of Alzheimer’s patients, separating them as monomers, oligomers and insoluble plaque. They then injected these separately into the brains of mice. To their surprise they found that memory was impaired only when soluble beta-amyloid oligomers were administered to the hippocampus (brain region where memory is stored) of the animals.

The exposure to soluble beta-amyloid reduced the density of dendrite spines (that actually receive and transit messages sent by other brain cells) in the hippocampus by almost half. This led the scientists to conclude that soluble beta-amyloid molecules act directly on synapses, the connections between neurons that are necessary for communication in the brain.

When they exposed the mice nerve cells to amyloid plaques from which soluble beta-amyloid had been removed, the researchers found that there was no disturbance in the brain signalling.

“We think that plaques are protective, but it’s the soluble oligomers that interrupt synaptic function,” says Selkoe.

“The study has put yet one more piece into place in the puzzle that is Alzheimer’s,” observes Richard Hodes, director of the US National Institute on Aging that financed the study.

The second study, by Lawrence Rajendran, a post-doctoral student at the Max Planck Institute of Molecular Cell Biology and Genetics at Dresden in Germany, and colleagues looks into the very formation of beta-amyloid. Their work shows that beta-secretase, an enzyme that chops down a molecule called amyloid precursor protein to make beta-amyloid, works only in a tiny compartment inside the brain cell.

Beta-secretase, which is found in the cells of many organs, is an innocent bystander most of the time, Rajendran told KnowHow. “Only when it is inside the endosome — a tiny compartment in brain cells — does it assume a villainous form,” he says. He thinks that if scientists can devise a strategy to attack beta-secretase inside the endosomes, they can control the production of beta-amyloid.

Yet another study by researchers in the UK and Canada, which appeared last week in Nature Cell Biology, says that the best way to treat Alzheimer’s is to trick the brain into not producing the tau protein, which forms the aggregates called tangles. The scientists, who studied the chemistry and structure of the tau protein, designed an enzyme inhibitor which uses a sugar molecule to lower the production of the protein.

With the new insights, scientists hope that the management of Alzheimer’s disease — which is estimated to cost more than $300 billion a year — may become easier. Perhaps there may soon be drugs that can treat the worst of neuro degenerative disorders.